Windows 10 1703 download iso italy covid 19 – windows 10 1703 download iso italy covid 19
Supported until October 14,with the latest feature updates. Windows 10 is a major release of Microsoft \’s Windows NT operating system. It is the direct successor to Windows 8. It was released to manufacturing on July 15,and later to retail on July 29, Windows 10 receives new builds on an ongoing basis, which are available at no additional cost to users, in addition to additional test builds of Windows 10, which are available to Windows Insiders.
Devices in enterprise environments can receive these updates at a slower pace, or use long-term support milestones that only receive critical updates, such as security patchesover their ten-year lifespan of extended support. Windows 10 received generally positive reviews upon its original release. Critics praised Microsoft\’s decision to provide the desktop-oriented interface in line with previous versions of Windows, contrasting the tablet-oriented approach of Windows 8, although Windows 10\’s touch-oriented user interface mode was criticized for containing regressions upon the touch-oriented interface of its predecessor.
Critics also praised адрес страницы improvements to Windows 10\’s bundled software over Windows 8. However, media outlets have been critical of the changes to operating system behaviors, including mandatory update installation, privacy concerns over data collection performed by the OS for Microsoft and its partners, and adware -like tactics привожу ссылку to promote the operating system on its release.
Microsoft initially aimed to have Windows 10 installed on over one billion devices within three years of its release;  that goal was ultimately reached almost five years after release on March 16, and is by now most used version in virtually all countries.
By JanuaryWindows 10 surpassed Windows 7 as the most popular version of Windows worldwide. On June 24,Microsoft announced Windows 10\’s successor, Windows download powerpoint free 2010 download freewhich was released on October 5, In Decembertechnology writer Mary Jo Foley reported that Microsoft was working on an update to Windows 8 codenamed \”Threshold\”, after a planet in продолжить Halo franchise.
She also stated that one of the goals for Threshold was to create a unified application platform and development toolkit for Windows, Windows Phone and Xbox One which all use a similar kernel based on Windows NT. The new Start menu takes after Windows 7 \’s design by using only a portion windows 10 1703 download iso italy covid 19 – windows 10 1703 download iso italy covid 19 the screen and including a Windows 7-style application listing in the first column.
The second column displays Windows 8-style app tiles. Myerson said that these changes would occur in a future update, but did not elaborate. Windows Phone 8. Screenshots of a Windows build purported to be Threshold were leaked in Julyshowing the previously presented Start menu and windowed Windows Store apps,  followed by a further screenshot of a build identifying itself as \”Windows Technical Preview\”, http://replace.me/28093.txtin Septembershowing a new virtual desktop system, a notification center, and a new File Explorer icon.
On September 30,Microsoft officially announced that Threshold would be unveiled during a media event as Windows Myerson said that Windows 10 would be Microsoft\’s \”most comprehensive platform ever\”, providing a single, unified platform for desktop and laptop computers, tabletssmartphones, and all-in-one devices. In regards to Microsoft naming the new operating system Windows 10 instead of Windows 9, Terry Myerson said that \”based on the product that\’s coming, and just how different our approach will be overall, it wouldn\’t be right to call it Windows 9.
We\’re trying to create one platform, one eco-system that unites as many of the devices from the small embedded Internet of Things, through tablets, through phones, through PCs and, ultimately, into the Xbox.
Further details surrounding Windows 10\’s consumer-oriented features were presented during another media event held on January 21,entitled \”Windows The Next Chapter\”.
Additional developer-oriented details surrounding the \” Universal Windows Platform \” concept were revealed and discussed during Microsoft\’s Build developers\’ conference.
Among them were the unveiling of \”Islandwood\”, which provides a middleware toolchain for compiling Objective-C -based software particularly iOS to run as universal apps on Windows 10 and Windows 10 Mobile. A port of Candy Crush Saga made using the toolkit, which shared much of its code with the iOS version, was demonstrated, alongside the announcement that the King -developed game would be bundled with Windows 10 at launch.
At the Ignite conferenceMicrosoft employee Jerry Nixon stated that Windows 10 would be the \”last version of Windows\”, a statement that Microsoft confirmed was \”reflective\” of its view of the operating system being a \”service\” with new versions and updates to be released over time.
On June 1,Microsoft announced that Windows 10 would be released on July 29, The commercials focused on the tagline \”A more human way to do\”, emphasizing new features and technologies supported by Windows 10 that sought to provide a more \”personal\” experience to users. Windows 10 makes its user experience and functionality more consistent between different classes of device, and addresses most of the shortcomings in the user interface that were introduced in Windows 8.
Windows 10 supports universal appsan expansion of the Metro-style first introduced in Windows 10 1703 download iso italy covid 19 – windows 10 1703 download iso italy covid 19 8. Both interfaces include an updated Start menu which incorporates elements of Windows 7 \’s traditional Start menu with the tiles windows 10 1703 download iso italy covid 19 – windows 10 1703 download iso italy covid 19 Windows 8.
Windows 10 also introduced the Microsoft Edge web browsera virtual desktop system, a window and desktop management feature called Task Viewsupport for fingerprint and face recognition login, new security features for enterprise environments, and DirectX Windows apps share code across platforms, have responsive designs that adapt to the needs of the device and available inputs, can synchronize data between Windows 10 devices including notifications, credentials, and allowing windows 10 1703 download iso italy covid 19 – windows 10 1703 download iso italy covid 19 multiplayer for gamesand are distributed through the Microsoft Store rebranded from Windows Store since September The ARM version of Windows 10 allows running applications for x86 processors through bit software emulation.
On Windows 10, the Microsoft Store serves as a unified storefront for apps, video content, and eBooks. Desktop software distributed through Windows Store is packaged using the App-V system to allow sandboxing. A new iteration of the Start menu is used on the Windows 10 desktop, with a list of places and other options on the left side, and tiles representing applications on the right.
The menu can be resized, and expanded into a full-screen display, which is the default option in Tablet mode. When a window is snapped to one side of the screen, Task View appears and the user is prompted to choose a second window to fill the unused side of the screen called \”Snap Assist\”. Charms have been removed; their functionality in universal apps is accessed from an App commands menu on their title bar.
It is accessed by clicking an icon in the notification area, or dragging from the right of the screen. Notifications can be synced between multiple devices. Windows 10 is designed to adapt its user interface based on the type of device being used and available input methods.
It offers windows 10 1703 download iso italy covid 19 – windows 10 1703 download iso italy covid 19 separate user interface modes: a user interface optimized for mouse and keyboard, and a \”Tablet mode\” designed for touchscreens. Users can toggle between these two modes at any time, and Windows can prompt or automatically switch when certain events occur, such as disabling Tablet mode on a tablet if a keyboard or mouse is plugged in, or when a 2-in-1 PC is switched to its laptop state.
In Tablet mode, programs default to a maximized view, and the taskbar contains a back button and hides buttons for opened or pinned programs by default; Читать View is used instead to switch between programs. The full screen Start menu is used in this mode, similarly to Windows 8, but scrolls vertically instead of horizontally. Windows 10 incorporates multi-factor authentication technology based upon standards developed by the FIDO Alliance.
Devices with supported cameras requiring infrared illumination, such as Intel RealSense allow users to log in with iris or face recognitionsimilarly to Kinect. Devices with supported readers allow users to log in through fingerprint recognition.
Support was also added for palm-vein scanning through a partnership with Fujitsu in February Inresearchers demonstrated that Windows Hello could be bypassed on fully-updated Windows 10 version with a color printout of a person\’s picture taken with an IR camera.
However, a PIN is not a simpler password. While passwords are transmitted to domain controllersPINs are not. They are tied to one device, and if compromised, only one device is affected. As such, the authentication token transmitted to the server is harder to crack. In addition, whereas weak passwords may be broken via rainbow tablesTPM causes the much-simpler Windows PINs to be resilient to brute-force attacks.
When Windows 10 was first introduced, multi-factor authentication was provided by two components: Windows Hello and Passport not to be confused with the Passport platform of Later, Passport was merged into Windows Hello.
Device Guard is designed to protect against zero-day exploitsand runs inside a hypervisor windows 10 1703 download iso italy covid 19 – windows 10 1703 download iso italy covid 19 that its operation remains separated from the operating system itself. Other features such as word wrap and transparency were also added. These functions can be disabled to revert to the legacy console if needed. The Anniversary Update added Windows Subsystem for Linux WSLwhich http://replace.me/458.txt the installation of a user space environment from a supported Linux distribution that runs natively on Windows.
The subsystem translates Linux system calls to those of the Windows NT kernel only claims full system call compatibility as of WSL 2, included in a later Windows update. The environment can execute the Bash shell and bit command-line programs WSL 2 also supports bit Linux нажмите для продолжения and graphics, assuming supporting software installed,  and GPUs support for other uses .
Windows applications cannot be executed from the Linux environment, and vice versa. To reduce the storage footprint of the operating system, Windows 10 automatically compresses system files. The system can reduce the storage footprint of Windows by approximately 1. The level of compression used is dependent on a performance assessment performed during installations or by OEMswhich tests how much compression can be used without harming operating system performance.
Furthermore, the Refresh and Reset functions use runtime system files instead, making a separate recovery partition redundant, allowing patches and updates to remain installed following the operation, and further reducing the amount of space required for Windows 10 by up to 12 GB.
Windows 10 1703 download iso italy covid 19 – windows 10 1703 download iso italy covid 19 10 introduces Microsoft Edgea new default web browser. Windows 10 1703 download iso italy covid 19 – windows 10 1703 download iso italy covid 19 initially featured a new standards -compliant rendering engine derived from Tridentand also includes annotation tools and integration with other Microsoft platforms present within Windows Windows 10 incorporates a universal search box located alongside the Start and Task View buttons, which can be hidden or condensed into a single button.
Many of its features are a direct carryover from Windows Phone, including integration with Bingsetting reminders, a Notebook feature for managing personal information, as well as searching for files, playing music, launching applications and setting reminders or sending emails. Microsoft Family Safety is replaced by Microsoft Family, a parental controls system that applies across Windows platforms and Microsoft online services.
Users can create a designated family, and monitor and restrict the actions of users designated as children, such as access to websites, enforcing age ratings on Microsoft Store purchases, and other restrictions. The service can also send weekly e-mail reports to parents detailing a child\’s computer usage.
Credentials are stored in an encrypted form on Microsoft servers and sent to the devices of the selected contacts. Passwords are not viewable by the guest user, and the guest user is not allowed to access other computers or devices on the photoshop cc 2022 free. Wi-Fi Sense is not usable on Universal calling and messaging apps for Windows 10 are built in as of the November update: Messaging, Skype Video, and Phone. These offer built-in alternatives to the Skype download and sync with Windows 10 Mobile.
Windows 10 provides greater integration with the Xbox ecosystem. Xbox SmartGlass is succeeded by the Xbox Console Companion formerly the Xbox appwhich allows users to browse their game library including both PC and Xbox console gamesand Game DVR is also available using a keyboard shortcutallowing users to save the last 30 seconds of gameplay as a video that can be shared to Xbox Live, OneDrive, or elsewhere.
Windows 10 adds native основываясь на этих данных recording and screenshot capture ability using the newly introduced Game Bar. Users can also have the OS continuously record gameplay in the background, which then allows the user to save the last few moments of gameplay to the storage device. Windows 10 adds three new default typefaces compared to Windows 8, but omits several others. The removed typefaces are available in supplemental packs and may be added manually over a non-metered internet connection.
Windows 10 is available in five main editions for personal computing devices; the Home and Pro editions of which are sold at retail in most countries, and as pre-loaded software on new computers. Home is aimed at home users, while Pro is aimed at power users and small businesses. Each edition of Windows 10 includes all of the capabilities and features of the edition below it, and adds additional features oriented towards their market segments; for example, Pro adds additional networking and security features such as BitLockerDevice Guard, Windows Update for Business, and the ability to join a domain.
Enterprise and Education, the other editions, contain additional features aimed towards business environments, and are only available through volume licensing. As part of Microsoft\’s unification strategies, Windows products that are based on Windows 10\’s common platform but meant for specialized platforms are marketed as editions of the operating system, rather than as separate product lines.
Моему windows 10 64 installer моему updated version of Microsoft\’s Windows Phone operating system for smartphones, and also tablets, was branded as Windows 10 Mobile. On May 2,Microsoft unveiled Windows 10 S referred to in leaks as Windows 10 Clouda feature-limited windows 10 1703 download iso italy covid 19 – windows 10 1703 download iso italy covid 19 of Windows 10 which was designed primarily for devices in the education market competing, in particular, with ChromeOS netbookssuch as the Surface Laptop that Microsoft also unveiled at this time.
The OS restricts software installation to applications obtained from Microsoft Store; the device may be upgraded to Windows 10 Pro for a fee to enable unrestricted software installation.
Windows Mobile Device Center: Using it in Windows 10 | Topcon Positioning Systems, Inc.
WebDownload Windows 10 Disc Image (ISO File) Before updating, please refer to the Windows release information status for known issues to confirm your device is not impacted. . WebThis help content & information General Help Center experience. Search. Clear search. WebJun 18, · In light of the current global situation regarding COVID, ISO has decided that all ISO governance and technical meetings planned until 30 April .
[Windows 10 – Wikipedia
Retrieved April 1, Retrieved December 10, Retrieved July 30, January 6, Retrieved May 2, Houston Chronicle. Hearst Corporation. Archived from the original on July 22, The Verge. Vox Media. Retrieved May 26, Retrieved April 22, Retrieved April 7, Retrieved September 30, The Start menu is coming back to Windows\”. Archived from the original on February 3, Retrieved March 31, The Slate Group.
Seattle Times. Seattle Times Network. Archived from the original on September 30, Retrieved November 5, Ziff Davis. February 2, September 30, The Guardian. Thomson Reuters. Business Insider. January 21, Retrieved January 24, PC Magazine. Ziff Davis Media. Conde Nast. Purch Inc. Archived from the original on March 2, Retrieved June 16, Archived from the original on April 9, Retrieved July 25, Retrieved July 17, Retrieved July 23, The New York Times. July 13, Tom\’s Guide.
Retrieved August 12, Retrieved April 3, Retrieved May 16, Windows Blog. Retrieved March 9, Retrieved February 7, December 7, Retrieved December 8, Windows Experience Blog. PC Pro. July 29, April 23, Retrieved July 16, March 20, Microsoft says Hello to palm-vein biometrics\”. Retrieved February 10, March 17, Retrieved March 17, Retrieved July 18, Microsoft Docs.
Retrieved October 30, Windows Developer Blog. June 17, Retrieved January 2, This means you can now use WSL for machine learning, artificial intelligence, and data science scenarios more easily when big data sets are involved.
Scott Hanselman\’s Blog. Windows PowerShell Blog. Archived from the original on April 2, Retrieved March 20, Retrieved January 23, Retrieved April 29, Retrieved March 25, June 15, Retrieved August 26, Retrieved January 9, Retrieved October 21, Retrieved October 22, Retrieved May 17, May 21, Retrieved May 22, August 11, Retrieved September 12, Archived from the original on August 11, Retrieved January 21, Xbox Blog.
February 13, Retrieved March 18, Retrieved February 14, Xbox Wire. May 14, Retrieved May 15, Archived from the original on December 1, Retrieved April 2, Retrieved November 15, MKV and.
FLAC files all on its own\”. PC Games Hardware in German. May 5, Retrieved April 11, DirectX Developer Blog. Archived from the original on October 4, Retrieved October 3, October 3, March 21, Retrieved June 20, PC Perspective. Archived from the original on September 5, Retrieved August 22, May 13, Retrieved May 13, Retrieved February 3, May 2, February 3, Retrieved March 11, April 21, Retrieved April 23, Retrieved March 8, Retrieved October 1, October June 21, Retrieved June 22, Conde Nast Digital.
June 22, Retrieved June 23, Retrieved June 21, Purch, Inc. Retrieved July 27, July 15, Retrieved July 15, Retrieved August 4, November 30, Redmond Magazine. Retrieved August 6, Retrieved July 31, Supersite for Windows. Archived from the original on August 1, March 18, May 19, Retrieved May 21, Retrieved July 14, Retrieved May 18, Windows Help.
Archived from the original on May 1, Retrieved February 1, May 16, While our free offer to upgrade to Windows 10 will not apply to Non-Genuine Windows devices. March 19, Retrieved March 19, Retrieved August 13, July 31, Windows 10 blog.
Microsoft Corporation. October 12, Retrieved October 12, Retrieved July 4, Network World. July 28, We highly recommend that you run the bit drvupdate-amd You may sometimes need to re-apply and Start these again when re-connecting device or after performing a Restart on the PC. Even if you are not able to get WMDC to show it is connected, you may still be able to browse the contents of the device through File Explorer which will appear as a drive under \”This PC\” or synchronize anyway.
This is as shown below:. Also, tests so far have shown that Windows Mobile Device Center seems to work as well in Windows 10 as it did in Windows 8, 7, and Vista. Some known issues may still apply. If you have been forced to download and re-install Windows Mobile Device Center in Windows 10, it is recommended to use the bit or bit links at the following web page. We promise not to sell or share your contact information and we won\’t contact you for any other purpose. Pharmacoepidemiol Drug Saf ;22 3 — A description of signals during the first 18 months of the EMA pharmacovigilance risk assessment committee.
Drug Saf ;37 12 — Raine J. Risk management: a European Regulatory view. Clinical pharmacology and therapeutics, 3 , — Research has proven that when patients are admitted to hospital, there are often changes to medication regimens 2, 3. Further research is necessary to establish if pharmacists\’ interventions on ensuring safety during patients\’ healthcare journey from hospital admission to discharge, differs between MDS using patients and non-MDS using patients.
Objective: The aim of this study was to analyse hospital pharmacists\’ interventions for patients\’ healthcare journeys for MDS using and non-MDS using patients. The study took place over four months from 1st July to 31st October There were initially admission episodes included in the study, and for each adult patient their healthcare journey from hospital admission to discharge was analysed for interventions and workforce input. Interventions were ranked using the validated Eadon Scale 4.
Results: A total of patients\’ healthcare journeys were analysed. Patients whom did not have complete healthcare journeys from hospital admission to discharge were excluded. These patients had either died, had been transferred to another hospital, or were still inpatients when the study ended. There were Of the total MDS using patient journeys, Of the total non-MDS using patient journeys, Conclusion: This study has identified that the use of MDS increase the burden to pharmacist workforce input.
It is evident from the findings, that interventions may be needed for the majority of MDS using patients. It has highlighted that more significant interventions, Eadon Scale 5, are more prevalent for MDS using patients in comparison to non-MDS using patients.
Relationship of in-hospital medication modifications of elderly patients to postdischarge medications, adherence, and mortality. Ann Pharmacother. Drug changes at the interface between primary and secondary care. Int J Clin Pharmacol Ther. Eadon H.
Assessing the quality of ward pharmacists\’ intervention. International Journal of Pharmacy Practice. Validation of a hospital clinical pharmacy workforce calculator: a methodology for pharmacy?
International Journal of Clinical Practice. Introduction: Hypertension is a serious disease that occurs when blood pressure is persistently elevated over time 1. During the COVID vaccination campaign, several reports of hypertension occurred in plausible temporal relationship with immunization have been reported. Data have been extract on May 8th, All other reports have been defined as non-cases.
All reports in which the suspected causative agent was a COVID vaccine were used as index reports and all other reports as reference. A meta-analysis of observational studies that includes , individuals reported 13, events of blood pressure abnormal or increased 2.
These events have been often described as short periods of hypertensive response and often observed in patients with risk factors. Conclusion: Our results confirmed a signal of risk of events of elevated blood pressure following immunization with COVID vaccines.
However, there is no evidence that these episodes could result in serious complication typically associated with hypertension, such as stroke, aneurysms, heart failure, myocardial infarction and chronic kidney disease.
Introduction: Intravitreal drugs such as bevacizumab, ranibizumab, and aflibercept are widely used to treat a wide range of retinal diseases. Several studies suggest that repeated injections of these drugs may lead to a sustained rising of intraocular pressure increasing risk for glaucoma. To date, a comparative safety study of these three drugs with respect to the incidence of glaucoma diagnosis has not been done.
Objective: The objective of this study was to evaluate the risk of glaucoma diagnosis compared among new users of bevacizumab, ranibizumab, and aflibercept in Tuscany. Methods: A retrospective cohort study using the Tuscan regional administrative database was conducted. Subjects with a first intravitreal injection index date between January —June were identified and followed to the first occurrence of glaucoma diagnosis. Patients with less than a five-year look-back period, those with less than one year of follow-up, and those with previous use of intravitreal dexamethasone, diagnosis of diabetes or glaucoma were excluded.
We also excluded patients for whom we could not track the first injection to bevacizumab, ranibizumab or aflibercept. Glaucoma diagnosis was identified from exemptions, diagnosis in hospital discharge records or drug dispensations.
An intention-to-treat analysis was conducted to analyze risk of glaucoma diagnosis between the three drugs. A Cox model was constructed to compute hazard ratios adjusting for age, sex comorbidities, corticosteroid use and binocularity. The risk of incident glaucoma diagnosis compared to aflibercept was significantly higher among non-anticoagulant users who had received ranibizumab HR 2. Among anticoagulant users no statistically significant difference was observed.
Moreover, we found an increase in the risk of glaucoma with ranibizumab and bevacizumab compared to aflibercept among non-anticoagulant users. A time dependent exposure analysis is ongoing to confirm these results. Introduction: A method of time-to-onset TTO signal detection for screening unexpected temporal patterns from vaccine spontaneous report data has been published in .
Due to the large number of spontaneous reports associated to covid vaccines, highly significant TTO signals could be detected whereas there are no clinically relevant unexpected temporal patterns. Methods: The revised method used only the most predictive measure  of the two Kolmogorov-Smirnov KS tests originally designed: the p-value of the KS test of the TTO distribution of a given event post a given vaccine against the TTO distribution of the same event post other vaccines.
A threshold on the Kolmogorov-Smirnov distance, that can have values between 0 and for no difference between time-to-onset distributions and 1 for extreme differences—was set at 0. A threshold on the p-value of the KS test was set at 0. The Vaccine Adverse Event Reporting System was prospectively frozen every week of the first quarter and the revised TTO signal detection method was prospectively applied on the two covid vaccines.
The performance in detecting events that were posteriori determined as causally related to the exposure of the covid vaccines, namely Pericarditis and Myocarditis, was retrospectively assessed. Conclusion: The revised TTO method allowed early detection of unexpected TTO patterns post exposure to covid vaccines by controlling both the level of significance and the magnitude of difference between the TTO distributions in a context of mass vaccination where individual case review is challenging.
Van Holle L et al. Using time-to-onset for detecting safety signals in spontaneous reports of adverse events following immunization: a proof-of-concept study, PDS 21 6 , — Use of logistic regression to combine two causality criteria for signal detection in vaccine spontaneous report data, Drug Safety 37 12 , — With the fast-tracked development and concurrent introduction of vaccines in all countries, there is a need for equitable safety surveillance to monitor adverse events following immunization AEFIs in high-income and low- and middle-income countries LMICs.
Reports from females made up The highest number of reports came from persons 18—44 years. Sputnik V contributed the highest percentage of AEs per vaccine for Africa. Headache, pyrexia, injection site pain, dizziness, and chills were the top 5 reported AEs for Africa and RoW. Qualitative findings revealed decisions of many funding organizations to fund safety surveillance in LMICs were influenced by considerations about country priorities, the perceived utility of the evidence generated for local decision making, and the contributions to global health by safety surveillance systems.
Funding decisions by donor organizations were influenced by country priorities and the perceived value added by data generated from safety surveillance systems in LMICs to local and global decision making. Coronavirus Vaccine Tracker. The New York Times [Internet]. Introduction: Therapeutic advances have reduced morbidity and mortality, but have led to an increase in adverse drug events ADE. This is a case-control type study, with the original information from the administrative data from the hospital information system of the public health system in Brazil-SIH-SUS, in the period from to After applying the exclusion criteria, , hospital admissions associated with at least one ADE were included in the study.
The proportion of patients with ADE in hospitalizations was 0. Drug poisoning and drug abuse are the adverse event classes most associated with increased risk of death. This study, confirm that the SIH-SUS is a robust source of data for the field of pharmacovigilance, enabling the identification of risk factors for death and facilitating the monitoring of ADEs in the hospital environment. Mortality among patients due to adverse drug reactions that occur following hospitalisation: a meta-analysis.
Prospective identification versus administrative coding of adverse drug reaction-related hospitalizations in the elderly: A comparative analysis.
Pharmacoepidemiol Drug Saf. Evaluating adverse drug event reporting in administrative data from emergency departments: a validation study. Stausberg J, Hasford J. Drug-related admissions and hospital-acquired adverse drug events in Germany: a longitudinal analysis from to of ICDcoded routine data. Introduction: Transplant recipients are chronically ill patients, who require lifelong drug therapies to prevent reject and graft loss.
To date, there is no consensus on the optimal immunosuppressive strategy . Objective: The aim of the study was to assess the effectiveness and safety of maintenance immunosuppressive drug therapies in kidney transplant. Methods: A retrospective multicentre observational study, involving 4 Italian regions, was conducted based on the national transplant Information system and regional healthcare claims data. Specifically, the regional analytical datasets regarding incident patients underwent to kidney transplant in the years —19 were created using an open-source tool for distributed analysis.
Results: Overall, 3, kidney recipients were considered, of which During a median follow-up period of 4. Among safety outcomes, serious infections had the highest incidence 9.
Conclusion: In clinical practice, a significantly better benefit profile has been demonstrated for kidney recipients treated with TAC compared to CsA.
In particular, the combination of TAC and mTOR appears to be the optimal strategy reducing the incidence of severe infections. Our findings on long term risk-benefit profile of immunosuppressive therapy may be helpful to define the optimal drug therapy in kidney recipients. Comparison of tacrolimus and cyclosporine for immunosuppression after renal transplantation: An updated systematic review and meta-analysis.
Saudi J Kidney Dis Transpl. Target of rapamycin inhibitors TOR-I; sirolimus and everolimus for primary immunosuppression in kidney transplant recipients. Cochrane Database Syst Rev. Timing of mTORI usage and outcomes in kidney transplant recipients. Int J Med Sci. Published Jan 9. Due to the small sample size of pivotal trials in pediatrics, real-world evidence on the safety of those vaccines in the pediatric population is urgently required.
Objective: i To investigate the safety of COVID vaccines by measuring frequencies of solicited and serious adverse events following immunization AEFIs with the first and the second doses of vaccines through active surveillance and, ii to compare the results with the published clinicaltrials in children and adolescents.
Of them, only Overall, Conclusion: This study confirmed safety profile of COVID vaccines in the pediatric population as already documented in the pivotal trials, with a high frequency of local solicited adverse events and an extremely low rate of serious adverse events. Introduction: Advances in the treatment of cancer in young patients have led to great improvements in life expectancy.
However, treatment with chemo or radiotherapy causes reduction of sperm counts often to azoospermic levels that may persist for several years or be permanent. Oligospermia or azoospermia and long-lasting testicular atrophy are common adverse consequences of cancer treatment 1.
Cases of oligospermia and azoospermia were identified using MedDRA v No Dis-Rep was found for any of the 14 AA TKIs: acalabrutinib, axitinib, cabozantinib, dacomitinib, lenvatinib, neratinib, nintedanib, pazopanib, ponatinib, regorafenib, sorafenib, sunitinib, tivozanib and vandetanib. The analysis in VigiBase database yielded similar results. Our results however, should be interpreted with caution as disproportionality analyses are hypothesis generating rather than hypothesis testing. Meistrich, M.
Clinical drug investigation. Bate A, Evans S. Quantitative signal detection using spontaneous ADR reporting. A comparison of measures of disproportionality for signal detection in spontaneous reporting systems for adverse drug reactions. Skin lightening products contain high concentrations of harmful ingredients such as hydroquinone, mercurials, and corticosteroids, and are reported to cause serious complications such as hyperpigmentation, exogenous ochronosis, wound dehiscence, nephropathy, steroid addiction syndrome, predisposition to infections, and other endocrinologic complications.
Despite all these public health risks, they have been used in many countries without regulation and consultation of healthcare professionals 3. Similarly, in Eritrea, there is uncontrolled marketing and use of SLAs even those with banned harmful ingredients. Objective: This study was conducted to assess the perception and utilization of SLAs among females of Asmara, the capital city of Eritrea.
Methods: A cross-sectional descriptive study was conducted in representative samples of all beauty salons available in Asmara between May and July The study participants were selected using two-stage stratified cluster sampling technique. The data collected through face-to-face interview was entered and analyzed using CSPro 7. Results: The study enrolled females.
The majority of the respondents agreed that SLAs can make someone white About two-third Of those who ever used SLAs, About half of the respondents With the use of SLAs, Employed females AOR: 1. Conclusion: Utilization of SLAs among females was prevalent. They were satisfied with its use despite experiencing adverse effects which urges coordinated efforts in tightening the regulation of cosmetics in general and establishment of cosmetovigilance systems in particular.
Widespread use of toxic skin lightening compounds: medical and psychosocial aspects. Dermatologic Clinics, Afr Health Sci. The global prevalence and correlates of skin bleaching: a meta-analysis and meta-regression analysis. Int J Dermatol. Introduction: Drug therapy in paediatrics is often associated with uncertainties due to lack of data from clinical trials. Due to this off-label use, missing paediatric dosage forms and complex dose calculations, medication errors ME occur up to three times more frequently compared to adults .
Objective: The aim of the study was to investigate the nature, characteristics and preventability of drug-related hospital admissions in paediatrics. If parents had given consent for data transfer and further analysis, the suspected ADRs resp. MEs were subsequently validated by a blinded, independent expert team .
All ADRs and MEs were assessed with regard to their nature, preventability, severity and drug association. Results: Of Consent for further analysis was obtained for 9. Allergic conditions, seizures incl. Treatment noncompliance, accidental exposure to product and dosing problems mainly underdosing were primarily identified as MEs in connection with the use of antiepileptic drugs, insulins and analogues and other beta-lactam-antibacterials.
Conclusion: Drug-related hospital admissions play a significant role in paediatrics. Moreover, almost half of them are considered preventable and therefore result in unnecessary harm and treatment costs. Dosing databases, training, and systematic screening for ADRs and MEs have great potential to increase the safety of drug therapy in children.
Kimland, E. Odlind, Off-label drug use in pediatric patients. Clin Pharmacol Ther, Magalhaes, J. Eur J Clin Pharmacol, Kaushal, R. JAMA, Smyth, R. PLoS One, Gallagher, R. Schulze, C. J Patient Saf, The lack of staff trained in PV is one of the most serious limiting factors affecting the development of PV in resource-constrained settings.
Previous experiences suggest that blending learning programmes can be implemented in resource-limited countries to train health care professionals HCP with remarkable gains in terms of knowledge acquisition. Methods: We developed the blended-courses integrated with a Train of Trainers scheme .
Two e-learning courses were made available on a web-based application, together with a manual on how to combine the e-learning courses together with face-to-face interactions. The blended course were given in Tanzania, Eswatini and Nigeria. Results: In the three countries 95 participants were trained Table 1.
All participants completed the two courses and the mean score of the post-test was significantly greater than on the pre-test Table 1.
In the second level, the participants from the first training were training others. The majority of respondents to questionnaires have been satisfied, declared they felt more involved in PV and reported at least an ADR after the training both in the first and second level. The trends of reporting increased in the twelve months after the training if compared to the previous twelve months: vs and vs ICSRs were reported to Vigibase for Tanzania and Eswatini National Agency respectively.
Conclusion: Our results demonstrated that a blended course can reach an important number of participants and improve their knowledge. It is difficult to establish how much of the increase of reports was attributed to the blended learning training. Alammary A.
Blended learning models for introductory programming courses: a systematic review. Plos one. The views and opinions of authors expressed herein do not necessarily state or reflect those of EDCTP. Introduction: Considering data from the literature in favor of active educational intervention to teach pharmacovigilance, we describe an innovative model of distance learning clinical reasoning sessions CRS of pharmacovigilance with 3rd year medical French students.
Objective: The three main objectives were to identify the elements necessary for the diagnosis of an adverse drug reaction, report an adverse drug reaction and perform drug causality assessment.
Methods: The training was organized in 3 stages. First, students practiced clinical reasoning CRS by conducting fictive pharmacovigilance telehealth consultations. Second, students wrote a medical letter summarizing the telehealth consultation and analyzing the drug causality assessment.
This letter was sent to the teacher for a graded evaluation. In the third stage was a debriefing course with all the students. Results: Of the third-year medical students enrolled in this course, participated in the distance learning CRS.
The evaluation received feedback from students, with an average score of 8. The qualitative evaluation had only positive feedback. The students appreciated the different format of the teaching, with the possibility to be active. Conclusion: Through distance CRS of pharmacovigilance, medical students\’ competences to identify and report adverse drug reactions were tested. The students experienced the pharmacovigilance skills necessary to detect adverse drug reactions in a manner directly relevant to patient care.
The overall evaluation of the students is in favor of this type of method. Methods: This research used a qualitative inductive methodology through thematic analysis. The first step was to identify, through a literature review, current practices for herbal pharmacovigilance.
Based on the findings a semi-structured interview guide was designed, and purposive sampling was used to recruit the interview participants. By using a snowballing technique more potential participants were reached. Most of these recommendations are applicable worldwide, while some are limited to certain regions. Tong, A. Consolidated criteria for reporting qualitative research COREQ : a item checklist for interviews and focus groups. International Journal for Quality in Health Care, 19 6 , — Introduction: Although medical cannabis MC has been available in Canada since , lack of recognition of MC as a drug has restricted patient access.
The Quebec College of Physicians, between and , authorized MC use only within a research framework. Follow-up ended due to either MC discontinuation, loss to follow-up, 3 years follow-up, or end of data collection May , 6 months after the last patient in. Data were collected at inclusion and at follow-up visits every 3 months for the first 2 years, then at least once per year in the third year. MC mode of administration ingestion, inhalation, other , and cannabinoid content ratio tetrahydrocannabinol THC -dominant, cannabidiol CBD -dominant, or balanced were documented.
Results: 2, patients were enrolled in the registry mean age Over follow-up, 3. Reports included a total of AEs average 1. The most common PTs were dizziness Conclusion: There were no new safety concerns identified in the Registry, although notable differences in AE profile between modes of administration and cannabinoid content ratios should be considered by health professionals. Further work identifying and managing risk factors for AEs is warranted to maintain a favorable risk-benefit ratio for MC.
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